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Medical Marijuana For Migraines?

By on June 26, 2013

Summary (click to view)

  • Migraines are a common type of headache that can last for hours
  • Marijuana was prescribed as a migraine treatment by many 19th century doctors
  • Modern research suggests that compounds in marijuana (cannabinoids) may provide relief from migraines in a number of ways
  • Cannabinoids may help by reducing inflammation, pain, serotonin levels and abnormal blood flow
  • Although success stories have been reported by doctors, marijuana has not been tested on migraine sufferers in clinical studies

  • The cause of migraines is still unknown

    Scientists still don’t know what causes migraines – Migraines are a severe form of headache that are estimated to affect 15% of the worldwide population. Patients describe the attacks as throbbing sensations in a specific area of the head, usually accompanied by nausea, vomiting and extreme sensitivity to light and sound.

    Unfortunately, the cause of migraine attacks remain a mystery to researchers and many patients fail to obtain relief from currently available treatments.

    On the other hand, the use of medical marijuana as a migraine treatment dates back to the 19th century and – despite modern-day prohibition – has gradually rebounded in recent years.

    In fact, surveys conducted in California suggest that around 5% of medical marijuana patients use the substance for migraine relief.

    What Causes Migraines?

    Migraine headaches involve a complex array of underlying factors that researchers have yet to unravel. Still, studies have made some progress towards identifying the source of migraines.

    In addition to genetic factors, migraines have been linked to inflammation and abnormalities of specific areas of the brain, including the brain stem. Dilation of blood vessels in the brain and high serotonin levels are also believed to contribute to migraine headaches.

    19th Century Medicine

    Sir William Osler (1849-1919)

    Sir William Osler (1849-1919) is regarded as the founder of modern medicine

    Cannabis was widely prescribed by Western doctors throughout the latter half of the 19th century. Specifically, the use of cannabis as a treatment for migraines was supported by a number of prominent physicians of the time, including Sir William Osler.

    In 1915, Sir Osler wrote that ‘Cannabis indica is probably the most satisfactory remedy’ for migraines and cited others in recommending a ‘prolonged course’ of cannabis treatment.

    In the following year, Dr. Dixon, Professor of Pharmacology at the Kings’ College and the University of Cambridge, also wrote about the therapeutic benefits of smoked cannabis for headache sufferers.

    Interestingly, cannabis was included in various 19th century pharmacopoeias as a treatment for migraines.

    Unfortunately, modern-day research has yet to investigate the effectiveness of marijuana-based treatments in migraine patients. However, numerous studies conducted on animal models provide strong support for its therapeutic potential.

    The Role of Cannabinoids in Migraines

    The endocannabinoid system consists of cannabinoids produced naturally by the human body as well as the receptors they bind to in order to achieve their effects. These receptors are known as cannabinoid receptors and are found in high concentrations throughout the brain.

    Activity of cannabinoid receptors has been shown to have a positive impact on a wide range of factors involved with migraine headaches. As well, experts have suggested that a lack of endocannabinoids may contribute to the development and severity of migraine attacks.

    For instance, studies have identified low levels of endocannabinoids in patients with chronic migraine, which experts suggest could increase blood vessel dilation as well as pain from migraine attacks.

    Interestingly, an animal study published in 2007 found that increased activity of the endocannabinoid system led to a reduction in pain signals sent by the brain stem. The authors concluded that cannabinoids showed promise as a treatment for sufferers of migraines and other headaches, although psychoactive effects could be a problem for some users.

    “The data suggest that CB receptors may have therapeutic potential in migraine, cluster headache, or other primary headaches.” (Akerman et al., 2007)

    In another animal study published in 2011, researchers found further evidence of the potential for cannabinoids to relieve pain associated with migraines as well as the possible role of endocannabinoid system abnormalities in migraine attacks.

    “The study confirms that a dysfunction of the endocannabinoid system may contribute to the development of migraine attacks and that a pharmacological modulation of cannabinoid receptors can be useful for the treatment of migraine pain.” (Greco et al., 2011)

    Studies also suggest that endocannabinoids may reduce activity of specific serotonin receptors (5-HT3) involved with symptoms of nausea and pain. Other studies have found endocannabinoids and CBD to be effective at decreasing the activity of serotonin itself. THC has also been shown to minimize the release of serotonin from blood cells, all of which suggests a role for marijuana compounds in regulating serotonin levels in migraine patients.

    Finally, numerous studies show that cannabinoids found in marijuana – including THC and CBD – can have strong anti-inflammatory effects. In fact, an animal study published in 1973 found that THC was 20 times stronger than aspirin and nearly twice as strong as hydrocortisone in reducing acute inflammation.

    Human Case Studies

    Dr. Grinspoon is a Harvard Medical School graduate and professor.

    Dr. Grinspoon taught at Harvard Medical School

    Over the years, a number of researchers have published case reports documenting the effectiveness of medical marijuana in treating migraine headaches.

    In 1993, Dr. Lester Grinspoon co-wrote and published a book entitled Marihuana: The Forbidden Medicine, in which the use of marijuana for migraines was covered in detail. One story involved a migraine sufferer who had repeatedly failed to obtain relief from standard pharmaceuticals, eventually finding that small doses of marijuana worked best for managing their symptoms.

    Interestingly, migraines have also been reported by patients after regular cannabis use is stopped. A paper entitled ‘Marijuana and Migraine’ (El-Mallakh, 1987) presented 3 of such cases, noting that one patient was able to relief their migraine attacks by using cannabis again while the other 2 found standard drugs to work effectively.

    Finally, a more recent case study published in 2009 described the ability of marijuana to stop cluster headaches in a patient who had failed to obtain relief from traditional medications. Remarkably, the patient found marijuana to work within 5 minutes of taking the drug.

    But despite strong historical and anecdotal evidence of the effectiveness of medical marijuana for migraine headaches, clinical trials involving human patients have never been conducted. As such, migraine sufferers who turn to cannabis for relief are likely to face resistance from the medical community over the ‘unproven’ safety and effectiveness of this alternative headache treatment.

    • Keith Cassinger

      Truth on pot my butt. This site is created by a bunch of loser burn outs trying to justify their crutch behavior.

      • jsmootg

        You are a troll. I don’t smoke pot , but this offers me hope that there is something to cure the life long headaches I have experienced. I am currently taking 5 drugs to help with my pain, but they barely work.

        • Keith Cassinger

          Why not work on your MIND loser?

          • not named keith

            your a retard bro

            • Keith Cassinger

              I ain’t your “bro” you little pothead loser.

      • zach

        Excuse me. I get a mix of migraines and cluster headaches everyday. It almost always ends in me getting blurry vision and me wanting to bash my head against a wall just so i would pass out so I don’t have to feel the pain for awhile. Once I started smoking marijuana, my headaches stopped as long as I smoked everyday. If I stop for a day, then the headaches would come right back.

        • zach

          I have also tried 12 prescriptions for headaches, Excedrin, Advil, Tylenol, and Ibuprofen. Using them everyday over 16 years has made the effect of the pills stop.

          • Keith Cassinger

            Wow, what a loser you are.

        • Keith Cassinger

          Yeah, and THC is the first thing you turn to? loser. A lot of peolle get headaches and did not turn to weed you frickin burnout.

        • not named keith

          I would try the hemp oil eating iv tryed smoking and it does not help me at all

      • Juju

        Shut the F up Keith and get off here. Why are you even on here if you want to put people down that have real uses for THC?

        • Keith Cassinger

          Eat me punk burnout. Another loser burnout trying to make a case for your loser habit. NO uses for THC besides punk losers like you not wanting to deal with his problems. Never gonna convince those of us who know what a loser you are.

          • not named keith

            someones been drinking the hard stuff !

            • Keith Cassinger

              It would be better than reading the pussy burnout responses here on this site. How sickening the the waste of life “new burnouts” are today. Same as the old burnouts.

          • Sarah Jane Burke

            So, Keith, all these “pussy burnouts,” I assume you’re belief is that marijuana use causes this condition, maybe combined with other substances? Something caused them to become burnouts, right? Nobody’s born a “burnout.”

            So what’s your excuse? Alcohol? Traumatic brain injury? Genetic low IQ? Just an ignorant asshole? All of the above?

            Perhaps what you really need is to go fuck yourself. I just don’t think anyone here gives a shit what you think, assuming you do think.

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    • Dean Kolbinsky

      Keith, You are an idiot.

      • Keith Cassinger

        Dean, you are a burnout and a pussy.

    • Sam Smith

      Sounds like Keith needs to smoke some pot and chill the hell out. I have struggled with severe migraines for the past 8 years and about a year ago I decided to smoke weed in order to relieve some of the pain. It has worked wonders for me not to mention I didn’t have all of the side effects I got from my prescription medicine.

    • Kevin

      Keith is an idiot.. He probably drinks and smokes cigs. Blinded by the government and societies conspiracy on marijuwana. Calling everyone who smokes pot a loser while smoking a cigarette in his left hand and holding a beer in his right hand. You’re brainwashed, get over it.

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    • sudon’t

      I just read that CBD is a 5-HT 1a receptor agonist. This is interesting because this is how Sumatriptan works. Sumatriptan injection really works, killing my cluster headaches pretty rapidly, but this legal pharmaceutical is much more expensive than black market dope. If you have insurance that’ll pay for it, I highly recommend it. For the rest of us, and the many who’ll soon be joining our ranks, high CBD strains might offer some relief.

    • Dr Heyes

      Migraine and headache pain can be debilitating and severely affect sufferers’ quality of life. Marijuana’s inhibitory effect on serotonin type 3 receptors can diminish the onset of migraines and headaches. Interested in medical marijuana for the above medical condition or others, email me at // and place your order. Keep it Clean!

    • Dr Heyes

      Good read. Migraine and headache pain can be debilitating and severely affect sufferers’ quality of life. Marijuana’s inhibitory effect on serotonin type 3 receptors can diminish the onset of migraines and headaches. Interested in medical marijuana for the above medical condition or others, email me at // for inquiry and order.