Don't miss

Marijuana and Diabetes

By on June 12, 2013

Summary (click to view)

  • Diabetes is caused by a lack of insulin and results in  high blood sugar
  • Diabetes can also lead to a number of other symptoms, including pain and cardiovascular disease
  • Marijuana users have lower rates of obesity and other risk factors for diabetes
  • Research shows that cannabinoids can increase insulin production and protect the pancreas from inflammation
  • Marijuana-based treatments are also effective for neuropathic pain 
  • Insulin drugs help diabetics control their blood sugar

    TruthOnPot.com – Diabetes mellitus (also known as primary diabetes) affects approximately 8.3% of the US population and 6.8% of Canadians. In 2007, diabetes contributed to over 200,000 deaths in the US alone.

    Although the early development of insulin medications made diabetes treatable, no cure exists and symptoms tend to worsen as the disease progresses.

    Now, a growing body of evidence points to medical marijuana as a promising therapy. In fact, research shows that marijuana may not only be useful for managing symptoms of pain and cardiovascular disease, but also aid in combating the disease itself.

    What is Diabetes?

    Diabetes mellitus is a group of metabolic diseases characterized by high blood glucose levels. The two most common forms of diabetes are known as Type 1 and Type 2 diabetes.

    Type 1 diabetes is usually diagnosed in individuals under the age of 30 and involves an autoimmune attack on islet cells of the pancreas – cells that produce insulin. Approximately 10% of diabetics suffer from Type 1 diabetes.

    Type 2 diabetes is far more common and tends to affect individuals that are obese and over the age of 40. It is usually a result of a combination of defective insulin production and insulin resistance.

    In both types of diabetes, high blood sugar levels eventually lead to a variety of other metabolic and non-metabolic complications.

    The Role of Endocannabinoids

    Endocannabinoids are natural compounds found within all humans that happen to act in a similar way as plant-derived cannabinoids such as THC. Along with cannabinoid receptors, they make up what is known as the endocannabinoid system.

    Cannabinoid receptors have been identified in the pancreas, heart, blood vessels, nervous system and many other organs – all of which suggests a potential role for cannabinoids in treating diabetes.

    Interestingly, large-scale surveys have found lower prevalence rates of obesity and diabetes mellitus among marijuana users compared with non-users, suggesting the potential for cannabinoids to affect this disorder.

    Studies have also identified higher endocannabinoid levels (anandamide and 2-AG) in diabetic patients compared to healthy individuals.

    Marijuana and Insulin

    Insulin dysfunction is the underlying factor in diabetes as well as the primary target of medical treatment. Interestingly, the presence of cannabinoid receptors has been identified in cells of the pancreas that produce insulin.

    Studies involving human cell cultures have linked activation of CB1 receptors to an increase in insulin production. On the other hand, the role of CB2 receptors is conflicted, with some studies showing an increase in insulin secretion and others showing a decrease.

    Marijuana compounds may take on another therapeutic role in type 1 diabetes by regulating activity of the immune system. In an animal model of type 1 diabetes, THC demonstrated an incredible ability to counter autoimmune attacks. THC treatment was also able to preserve insulin levels and lower blood glucose levels compared with the untreated group.

    Other studies have found CBD (cannabidiol) and THCV (tetrahydrocannabivarin) – two non-psychoactive compounds found in marijuana – to have similar protective effects.

    A study published in 2006 found that CBD could reduce the chance of developing type 1 diabetes in mice by reducing inflammation of pancreatic cells. In a study involving obese mice, THCV treatment led to improved glucose tolerance, reduced glucose intolerance and increased insulin sensitivity, leading the authors to conclude that THCV could be a useful therapy for type 2 diabetes either alone or together with CBD.

    “Based on these data, it can be suggested that THCV may be useful for the treatment of the metabolic syndrome and/or type 2 diabetes, either alone or in combination with existing treatments… a CBD/THCV combination may be beneficial for different types of diabetes mellitus.”

    Excerpt from The cannabinoid Δ9-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity (Wargent et al., 2013)

    Finally, a large-scale observational study published in 2013 by Harvard University researchers found that adults who used marijuana had lower fasting insulin levels and a lower probability of being insulin resistant. The study collected data from over 4,500 adults during a 5 year period.

    Marijuana and Obesity

    Type 2 diabetes is commonly associated with obesity and related cardiovascular problems. Interestingly, the endocannabinoid system appears to be involved with obesity and regulating energy balance as well.

    Early studies revealed higher levels of the endocannabinoids anandamide and 2-AG in obese individuals, which led experts believed that activity of the endocannabinoid system promoted obesity. Along the same line, activity of the endocannabinoid system has been shown to decrease energy expenditure and increase food intake and fat storage.

    However, more recent evidence suggests an opposite effect on obesity.

    In the same Harvard University study, researchers found that marijuana users had lower waist circumferences, despite the fact that they tended to consume more calories. Similarly, a 2011 analysis of 2 large U.S. surveys linked marijuana use with a lower BMI and a decreased prevalence of obesity.

    Marijuana and Cardiovascular Disease

    Recent studies also suggest a therapeutic role of cannabinoids in a number of cardiovascular complications that accompany diabetes. As it turns out, CB1 and CB2 receptors are expressed in various cells of the cardiovascular system, including the immune cells that infiltrate them.

    In mouse models, cannabinoids have demonstrated the ability to regulate vascular inflammation, oxidative stress and atherosclerosis, leading experts to suggest that marijuana-based medications may be useful in the treatment of these dysfunctions.

    “Modulation of the endocannabinoid system… may hold tremendous therapeutic potential in various cardiovascular disorders associated with inflammation and tissue injury, ranging from myocardial infarction and heart failure to atherosclerosis and cardiometabolic disorders.”

    Excerpt from The emerging role of the endocannabinoid system in cardiovascular disease (Pacher and Steffens, 2009)

    Marijuana and Neuropathic Pain

    Approximately 60-70% of diabetics suffer from some form of nerve damage, which can often lead to a specific type of pain known as neuropathic pain.

    Interestingly, neuropathic pain has been one of the few applications of medical marijuana to be investigated in clinical trials. Sativex – a cannabis-derived oral spray – has already been approved by countries such as Canada and the United Kingdom for the treatment of pain associated with cancer and multiple sclerosis.

    While yet to be approved for diabetics, cannabis-based treatments have also shown promise in clinical trials involving diabetes-related neuropathic pain.

    A placebo-controlled clinical trial published in 2012 found that 85% of patients given synthetic THC (Cesamet) experienced a reduction in pain of at least 30%. Furthermore, all patients that received the strongest dose (4mg/day) experienced a reduction in pain of 30% or more. The study also identified significant improvements in overall disease scores. Side-effects were relatively minor and included confusion, drowsiness and dizziness.

    Finally, other studies show that cannabis use can lead to improvements in sleep, mood and quality of life in patients with neuropathic pain.

    • Wanessa Guedes

      Am from England and am
      very happy to write about Dr Ariba for what he has don for me and my Mom. We where both
      having dubieties Type 1 until that
      faithful day we found a post on the Internet of how a man was cure of that same diseases saying it cost him $1500
      for the herbal cure I quickly collected the email of the Dr and
      emailed him immediately and behold he requested for out information which
      I did and the he told us how much it was going to cost and when we payed
      the fees and he sent us a parcel through a courier service and when
      we received it we drank it as prescribed and after some days everything
      was finally over now am so so happy that am finally normal again. If you need his help you can email him
      on any of these draribaspelltemple@gmail.com or dr.aribaspelltemple@outlook.com or call his mobile number +2348140439497

    • Wanessa Guedes

      Am from England and am
      very happy to write about Dr Ariba for what he has don for me and my Mom. We where both
      having dubieties Type 1 until that
      faithful day we found a post on the Internet of how a man was cure of that same diseases saying it cost him $1500
      for the herbal cure I quickly collected the email of the Dr and
      emailed him immediately and behold he requested for out information which
      I did and the he told us how much it was going to cost and when we payed
      the fees and he sent us a parcel through a courier service and when
      we received it we drank it as prescribed and after some days everything
      was finally over now am so so happy that am finally normal again. If you need his help you can email him
      on any of these draribaspelltemple@gmail.com or dr.aribaspelltemple@outlook.com or call his mobile number +2348140439497…….

    • Helen Tolbert

      Dr. Ariba God will continue to bless you more
      abundantly, for the good works you are doing in peoples life, I will keep on
      writng and posting testimonies about you on the Internet, I’m Helen Tolbert, I
      was a HIV patient, I saw a blog on how Dr. Ariba cured someone, I contacted him
      and also got my healing, kindly email him now on dr.aribaspelltemple@outlook.com Or draribaspelltemple@gmail.com

    • Helen Tolbert

      Dr. Ariba God will continue to bless you more
      abundantly, for the good works you are doing in peoples life, I will keep on
      writng and posting testimonies about you on the Internet, I’m Helen Tolbert, I
      was a HIV patient, I saw a blog on how Dr. Ariba cured someone, I contacted him
      and also got my healing, kindly email him now on dr.aribaspelltemple@outlook.com Or draribaspelltemple@gmail.com….

    • greg dave

      we have top quality marijuana strains for sale text or call (567) 698 8469 or email … joshuamenez1137@gmail.com.

    • Michael Kenneth

      Grate Thanks to Dr. Henderson for Helping me cure my Diabetes within 3 months,
      A new restoration of Hope to all Diabetes Patients as your Diabetes can be cured under the use of Dr. Henderson medication
      When I was told by my doctor I had only 6 months before my diabetes could mean a stroke or heart attack I was beyond devastated.
      hendersonmedicalservice@yahoo.com is a sure way of having your Diabetes cured under 3 months treatment plan. Be free from Insulin forever
      After reading the diabetes miracle cure and implementing what you teach I was noticing almost instant results! It’s been 20 days and my blood sugar is finally under control, no matter what I eat or do.

      My doctor, aside from being totally confused by my recovery has said I am now no longer a diabetes sufferer, and it’s all thanks to what you showed me in using your medication and following your principles. diabetes patients should contact Dr. Henderson On: hendersonmedicalservice@yahoo.com

      Thank you, I am forever grateful.

      • Bill Williams

        I am enjoying the PURE BULLSHIT. STOP SPAMMING

    • Jack Allen

      Its a pleasure for me to write this testimony about this wonderful thing that happened to me last week on how i got my HIV aids cured, i have been reading so-many post of some people who were cured of HIV, but i never believed them, I was hurt and depressed so I was too curious and wanted to try dr.Ariba then i contacted him on his email on dr.aribaspelltemple@outlook.com, when i contact him, he assured me 100% that he will heal me, i pleaded with him to help me out, its a great success that he healed just as he promised, he told me that in three days time that i should go and check on my HIV status, I was floored that when i went to the hospital to check of my status that i was HIV negative, i never thought possible that dr.Ariba can do miracles, i never really believed in magic but I played along with a little hope and and faith and after everything but dr ARIBA changed my life and made me a true believer you can contact him on dr.aribaspelltemple@outlook.com, or draribaspelltemple@gmail.com so he can help you out

    • Jack Allen

      Its a pleasure for me to write this testimony about this wonderful thing that happened to me last week on how i got my HIV aids cured, i have been reading so-many post of some people who were cured of HIV, but i never believed them, I was hurt and depressed so I was too curious and wanted to try dr.Ariba then i contacted him on his email on dr.aribaspelltemple@outlook.com, when i contact him, he assured me 100% that he will heal me, i pleaded with him to help me out, its a great success that he healed just as he promised, he told me that in three days time that i should go and check on my HIV status, I was floored that when i went to the hospital to check of my status that i was HIV negative, i never thought possible that dr.Ariba can do miracles, i never really believed in magic but I played along with a little hope and and faith and after everything but dr ARIBA changed my life and made me a true believer you can contact him on dr.aribaspelltemple@outlook.com, or draribaspelltemple@gmail.com so he can help you out….

      • Bill Williams

        It is my pleasure to ignore you, you damn spammer you.

        • Jack Allen

          Its a pleasure for me to write this testimony about this wonderful thing
          that happened to me last week on how i got my HIV aids cured, i have
          been reading so-many post of some people who were cured of HIV, but i
          never believed them, I was hurt and depressed so I was too curious and
          wanted to try dr.Ariba then i contacted him on his email on
          dr.aribaspelltemple@outlook.com, when i contact him, he assured me 100%
          that he will heal me, i pleaded with him to help me out, its a great
          success that he healed just as he promised, he told me that in three
          days time that i should go and check on my HIV status, I was floored
          that when i went to the hospital to check of my status that i was HIV
          negative, i never thought possible that dr.Ariba can do miracles, i
          never really believed in magic but I played along with a little hope and
          and faith and after everything but dr ARIBA changed my life and made me
          a true believer you can contact him on dr.aribaspelltemple@outlook.com,
          or draribaspelltemple@gmail.com so he can help you out

        • http://careersreport.com Katherine Davis

          Here is a way how it is possible to get paid 65 bucks /an hour… After searching for a job that suits me for six months , I started earning over this website and now I possibly could not be more satisfied. After 3 months doing this my income is around^ five thousand bucksmonth -look out website given on my disqus

        • http://careersreport.com Rosana Whitt

          This is how) you can earn 65 bucks hour… After searching for a job that suits me for 6 months , I started working over this internet-website and today I possibly can not be more happy. After 3 months on my new job my income is around 5000 dollars/monthly -Visit link on MY~PROFILE~PAGE to see more

        • dawn.gallegos

          I am gaining roughly $6k-$8k /a month on the internet. For anyone eager to work basic computer-based task for few hours /day at your house and make valuable salary while doing it… This is ideal for you… KORTA.NU/NDe

    • MOZER GERGELY

      Hello my names are Mr Mozer Gergely and I’m giving a testimony about Dr. Akpore who cured me from Diabetes type 2, when I did the test and I was confirmed positive, I was so confused because my son is just too young and I need to be there for him, so I tried all means to make sure I will be there for him, I saw a blog where Dr. Akpore cured Diabetes, I contacted him through his email and i explained my problems to him, and he assured me of herbal total cure, he did what he has been doing for other people and after taking his Herbal medicine I was cured.Dr. Akpore also a asked me to go for check-up and i was negative again… I’m so happy and testifying about the effectiveness of Dr. Akpore John herbal medicine is real,you can contact him via email on mozergergely123@gmail.com

    • Shona Davies

      Yes!! Medical marijuana really works. i ordered some for my chronic pain and it magically relieved me of the pains and now my quality of life is better. i was surprised on how fast and safely it got delivered to me. Thanks to Kenneth!! I’ll recommend you contact him, for inquiries and orders.Here’s his contact, text/call (313) 288-9756 / Email…kennethbomar95@gmail.com

    • Dr Megan Ann

      Are you depressed, suffering from cancer, glaucoma, headache, insomnia, joint pains, multiply sclerosis, diabetes, muscle spasms, nausea, etc and need the best strains of medical marijuana to help ease your pain??
      Why not try out our wide range of products today??
      *Products (Medical Marijuana Strains, Cannabis Oil, Cannabis Capsules, Concentrates & Edibles). For more info, email: dr.megan.ann@gmail.com

      • Rose K.

        Your CBD oil has been the most effective pain relief I’ve found for my ongoing shoulder rotator cuff problem and knee pain. I use it as an anti-inflammatory and also to ease anxiety. Outstanding product!!!
        Doc you the best……her delivery was fast and 100% safe.

        • Henrik Hansson

          I just got my top shelf medical cannabis and cannabis oil delivered to me right to my door steps after a long period of search as i am suffering from chronic back pain and diabetes. I found luck by contacting Dr Megan. Quality products and Good prices too.

    • mariana

      Hello friends, I want to appreciate Doctor Oluwa for curing me of HIV with his Herbal medicine, i was at the point of death until i found a testimony of his good works,now am happy with joy in my heart to share this good news that am living a HIV free life. for my major purpose is to inform those that are in need of HIV cure to their cancer to contact this great healer, Doctor Oluwa via email on {{dr.oluwabosun@gmail.com}} and be HIV free just as i am. am so grateful god brought you to me Doctor Oluwa.I really appreciate you and thanks alots for curing my HIV…

    • Been Philip

      are you sick of diabetes of any kind?? if yes contact me today I have discover the cure for diabetes which will cure you from the diseases within 7 days for more information about getting the roots and herbs for the cure contact me via email greatezazawalter@gmail.com